How Does it Work?

There are 28 known naturally occurring alkaloids found in Tramasol™, and these alkaloids work together to produce powerful pain-relieving effects. The most dominant alkaloids are mitragynine and 7-hydroxymitragynine, both of which act as opioid receptor agonists. Aside from pain relief, the alkaloids in Tramasol™ also work on stimulating one’s cognitive abilities and enhancing overall mood.


Mitragynine consists of the majority of Tramasol™’s alkaloid content. While mitragynine’s effects will vary from person to person, here are the most common effects to be expected from this alkaloid:

  • Pain relief
  • Stimulation
  • Anti-malarial
  • Anti-diarrheal
  • Anti-tussive

Of these effects, the two most prominent are stimulation and pain relief. When you feel a sudden burst of energy or liveliness after taking Tramasol™, it is mostly the mitragynine working.

Mitragynine’s effects vary greatly depending on the dosage. At lower doses, mitragynine tends to be more stimulating. At increased doses, mitragynine can produce a calming effect that is good for treating pain.

Mitragynine has varying effects because it works with three different receptors in the brain. The effects that you feel vary according to how much mitragynine has interacted with these sensors.

When reacting with the adrenergic receptors, mitragynine is mainly a stimulant because it releases adrenaline into your body’s system.

When mitragynine interacts with mu opioid receptors, its primary effects are mostly for pain relief.


Although there is only very little of this alkaloid in Tramasol™, this is the most potent of them all. Unlike mitragynine, this alkaloid acts only in a very small area, thus making it act quicker and stronger.

However, taking this alkaloid alone can be too potent for one dose. Studies have shown that 7-hydroxymitragynine can have up to 10 times more strength than morphine.

7-hydroxymitragynine’s effective painkilling powers have turned Tramasol™ into a popular substitute for those undergoing opiate withdrawal. Many have successfully recovered from their opiate dependence due to a small quantity of this alkaloid.

Alkaloids in Tramasol™

Here are the main alkaloids present in Tramasol™ with their main uses.

  • 7-hydroxymitragynine – analgesic/painkiller (opioid receptor agonist), antidiarrheal, antitussive
  • Mitragynine – analgesic/painkiller (opioid receptor agonist), antidiarrheal, antitussive, adrenergic receptor agonist (mild stimulant), antimalarial
  • Speciogynine – smooth muscle relaxer
  • Mitraphylline – muscle relaxer, vasodilator, anti-hypertensive, anti-amnesic, immune system stimulant, anti-leukemic
  • Epicatechin (EGC) – antioxidant, antiviral, anti-mutagenic, anti-leukemic, anti-inflammatory, anti-diabetic. EGC is commonly found in green tea.
  • 9-Hydroxycorynantheidine – painkiller/analgesic
  • Corynantheidine – mu opioid antagonist
  • Isomitraphylline – immune system stimulant
  • Isomitrafoline – immune system stimulant
  • Isorhynchophylline – immune system stimulant
  • Isopteropodine – immune system stimulant
  • Ciliaphylline – analgesic, antitussive
  • Corynoxine A – dopamine mediator
  • Corynoxine B – dopamine mediator
  • Ajmalicine – sedative (anti-adrenergic), increases blood flow to brain, smooth muscle relaxer
  • Rhynchophylline – anti-inflammatory, vasodilator, anti-hypertensive
  • Speciociliatine – mild opioid receptor agonist
  • Speciophylline – anti-leukemic
  • Tetrahydroalstonine – anti-adrenergic, lowers blood sugar